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A Convenient Preparation of Alkyl Nitriles by the Mitsunobu Procedure

✍ Scribed by Wilk, Bogdan K.


Book ID
120340910
Publisher
Taylor and Francis Group
Year
1993
Tongue
English
Weight
158 KB
Volume
23
Category
Article
ISSN
0039-7911

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A convenient method for the alkylation o
✍ Jean-Yves Winum; VΓ©ronique Barragan; Jean-Louis Montero πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 69 KB

The alkylation of N-Boc-N%-(2-chloroethyl)sulfamide 1 by electron-deficient alkyl bromides using the Mitsunobu reagent as mild base is described. This method was also applied to the N-glycosylation of various carbohydrates and was anomerically selective.