A convenient method for the alkylation of sulfamides using alkyl bromides and Mitsunobu betaine

✍ Scribed by Jean-Yves Winum; Véronique Barragan; Jean-Louis Montero

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 69 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)02012-8

✦ Synopsis

The alkylation of N-Boc-N%-(2-chloroethyl)sulfamide 1 by electron-deficient alkyl bromides using the Mitsunobu reagent as mild base is described. This method was also applied to the N-glycosylation of various carbohydrates and was anomerically selective.