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A Convenient Preparation of a-Keto Esters by the Grignard Reaction on N-Acylpyrazoles

โœ Scribed by Kashima, Choji; Shirahata, Yoshie; Tsukamoto, Yoshihiro


Book ID
115544886
Publisher
Japan Institute of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
162 KB
Volume
49
Category
Article
ISSN
0385-5414

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The reaction of lithium ester enolates w
โœ Michael W. Rathke; Jeffrey Deitch ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 158 KB

Lithium ester enolates, prepared by the reaction of lithium N-isopropylcyclohexylamide (LIICA) with esters at -78' (eq. 1); react with acid chlorides at this same low temperature to provide satisfactory yields of the corresponding S-keto esters (eq. II). This procedure represents an exceedingly vers