The reaction of lithium ester enolates with acid chlorides. A convenient procedure for the preparation of β-keto esters

✍ Scribed by Michael W. Rathke; Jeffrey Deitch

• Publisher: Elsevier Science
• Year: 1971
• Tongue: French
• Weight: 158 KB
• Volume: 12
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)97034-0

✦ Synopsis

Lithium ester enolates, prepared by the reaction of lithium N-isopropylcyclohexylamide (LIICA) with esters at -78' (eq. 1); react with acid chlorides at this same low temperature to provide satisfactory yields of the corresponding S-keto esters (eq. II). This procedure represents an exceedingly versatile method for the preparation of a wide variety of these useful compounds.