A convenient preparation of 4-iodoindoles from indoles: application to the chemical synthesis of hapalindole alkaloids

✍ Scribed by Martyn A Brown; Michael A Kerr

• Book ID: 104211688
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 76 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)02194-8

✦ Synopsis

4-Iodoindoles were synthesized via regioselective chloromercuration and subsequent iodination of a series of N-p-toluenesulfonyl indoles bearing a variety of substituents at the 3-position This procedure allows rapid access to 3,4-dihaloindoles which may be used as synthetic precursors to indole alkaloids.