A Convenient Preparation of 3-Acetyl-5-methylisoxazole.
✍ Scribed by Ronald R. Sauers; Susan D. Van Arnum
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 79 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image A number of novel sulfonamide derivatives of 5‐substituted‐3‐methylisoxazole were synthesized and characterized, starting from 3,5‐dimethylisoxazole. Key steps include the generation of 3,5‐dimethylisoxazole‐4‐sulfonamides followed by their reactions with __N__‐(dimetho
## Abstract The preparation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) with deuterium α to the carboxylic acid group (2) and in the exocyclic methyl group (5), respectively, are described. The deuterium labelled AMPA (2) was synthesized by hydrolysis and decarboxylation of the c