A convenient new synthesis of α-fluorocarbonyl compounds

✍ Scribed by Albert J. Fry; Yoelit Migron

• Book ID: 104246405
• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 232 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)95408-5

✦ Synopsis

The reaction between tertiary a-bromo ketones or aldehydes and silver tetrafluoroborate in ether affords a-fluorocarbonyl compounds.

Neighboring group participation by the carbonyl oxygen is proposed to account for the products and by-products.

Published methods1 for the synthesis of a-fluoro ketones or aldehydes (L) suffer from the disadvantages of requiring several steps and/or inconvenient reagents.