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A convenient method for the preparation of dl-5-Methyltetrahydrofolic acid (dl-5-methyl-5,6,7,8-tetrahydropteroyl-l-monoglutamic acid)

โœ Scribed by J.A. Blair; K.J. Saunders

Book ID
107711077
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
293 KB
Volume
34
Category
Article
ISSN
0003-2697

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๐Ÿ“œ SIMILAR VOLUMES

Preparation of 5-alkyltetrahydrofolic ac
Preparation of 5-alkyltetrahydrofolic acids (dl-5-alkyl-5,6,7,8-tetrahydropteroyl-l-monoglutamic acids)
โœ J.A. Blair; K.J. Saunders ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 320 KB

## 5-Methyltetrahydrofolate (dl-5-methyl-5,6,7,8-tetrahydropteroyl-tmonoglutamic acid) has been prepared directly from folic acid without intermediate isolation of tetrahydrofolic acid (1). We now report the preparation of the ethyl, n-propyl, and n-butyltetrahydrofolates as their calcium salts. E

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## 5-Alkyl derivatives of dl-tetrahydromethotrexate have been prepared by reduction of methotrexate by sodium borohydride followed by reductive condensation with aldehyde and sodium borohydride and formation of the calcium salt (l-3). ## Methods Chemicals were obtained as follows: methotrexate,

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11: a .jrevious i >a':'-'??" the syz.t!xoi.o of 3-anino-2-inethylbutyric acid by the Rodiozow reactioc 2 from acetaldehyde-amonia and :Ilctilyl:.lalo;lic acid \*;]a0 reported. 'Tno diastareonors witi; m.p. 227-223" dcc. aid 213-214" dot. were isolated and several of their dorivativcs obtaii?ed. Ix o