A convenient high-yield preparation of phenylfluoroboranes
โ Scribed by Omar Farooq
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 197 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-1139
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๐ SIMILAR VOLUMES
RuO 2 /NaIO 4 oxidation of N-Boc-4-silyloxy and 4-acetoxy proline methyl esters under ethyl acetate/water biphase condition gave N-Boc-4-silyloxy and 4-acetoxy pyroglutamic acid derivatives in high yields. Desilylation with TBAF afforded both cis-and trans-N-Boc-methyl-4-hydroxy pyroglutamates.
Appropriate secondary amines are readily converted to nitroxides by dimethyldioxirane in a rapid, convenient, and essentially quantitative process. We earlier reported2 that dimethyldioxirane3, 1, oxidizes primary amines to nitro compounds in a facile, high yield process. While continuing our work
The high yield synthesis of 2-fluoropodophyllotoxin is presented. This preparation represents the first example of a 100% diastereospecific electrophilic fluorination.