A convenient catalytic route to symmetrical functionalized bithiophenes
✍ Scribed by Jwanro Hassan; Laurence Lavenot; Christel Gozzi; Marc Lemaire
- Book ID
- 104260520
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 111 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A series of symmetrical functionalized bithiophenes has been synthesized in good to excellent yields via homocoupling of thiophene halides in the presence of Pd(OAc)2 as a catalyst.
📜 SIMILAR VOLUMES
Mixed acetals of olefinic and acetylenic alcohols and $-carbonyl and other substituted aldehydes are readily obtained by acetoxymercuration followed by demercuration utilizing NaBH4 or Na2CS3.
## Abstract A new synthetic route to 4‐substituted‐2,2′‐bithiophenes has been developed utilizing 4‐bromo‐2,2′‐bithiophene (1). Formation of the bithienyllithium adduct __via__ halogen‐metal exchange was found to be problematic and resulted in complex mixtures of products. The Grignard reagent of 1