A conspicuous adaptability to antibiotics in the Escherichia coli mutator strain, dnaQ49
โ Scribed by Kiyoshi Tanabe; Takashi Kondo; Yoshikuni Onodera; Mitsuru Furusawa
- Book ID
- 109323098
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 262 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0378-1097
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A conditional lethal mutator, dnaQ49, was found in Escherichia coli K12. The dnaQ49 mutation caused stimulation of rifampicin-, nalidixic acid- and streptomycin-resistant mutation frequencies 100 to 2000 fold at 30 degrees C and the frequencies were further increased 50 to 100 fold at 35 degrees C o
A strain of E. coli K12 has been isolated which gives rise to mutations in a large number of ribosomal proteins. Mutant VT, which was derived from A19, shows a novel type of streptomycin dependence and has an altered ribosomal protein S8. Streptomycin-independent isolated from mutant VT contain a gr