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A Conjugated Polymer-Based Electrochemical DNA Sensor: Design and Application of a Multi-Functional and Water-Soluble Conjugated Polymer

✍ Scribed by Lanyong Zhang; Huan Sun; Di Li; Shiping Song; Chunhai Fan; Shu Wang

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 233 KB
Volume: 29
Category: Article
ISSN: 1022-1336
DOI: 10.1002/marc.200800260

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✦ Synopsis

Abstract

In this work, we report the design of a new multi‐functional, water‐soluble conjugated polymer integrating both a DNA intercalator and a redox label. Based on this multi‐functional conjugated polymer, we develop a sequence‐specific electrochemical DNA sensor, where the acridine unit serves as the basis for sequence discrimination, and the ferrocene label provides the electrochemical signal. Moreover, the conjugated polythiophene helps transfer electrons from ferrocene to the electrode. This sensor provides a new way for rapid and convenient detection of DNA targets.

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