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A conformational requirement for observable magnetic non-equivalence of benzylic methylene protons

✍ Scribed by Robert E. Lyle; John J. Thomas

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
213 KB
Volume
10
Category
Article
ISSN
0040-4039

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✦ Synopsis

The magnetic equivalence or non-equivalence of the methylene hydrogens of a benzyl group has proven to be an effective probe for chirality in a substrate.' An AB quartet for the nmr resonance signal of the aliphatic protons of a single benzyl substituent is positive evidence for chirality( in the system but the absence of this feature is not conclusive for achirality.

📜 SIMILAR VOLUMES

Conformationally dependent influence of
Conformationally dependent influence of 3-substituents on the observable magnetic non-equivalence of benzylic methylene protons in N-benzylpiperidines
✍ M. A. Iorio; A. F. Casy 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 388 KB

## Abstract Examples are given of the conformationally dependent influence of 3‐substituents (methyl, __n__‐propyl, allyl, aryl, hydroxy and acyloxy) on the magnetic non‐equivalence of the benzylic methylene protons (N__CH__~2~Ph) of __N__‐benzylpiperidine as observable by ^1^H NMR. The results, to