✦ LIBER ✦
Conformationally dependent influence of 3-substituents on the observable magnetic non-equivalence of benzylic methylene protons in N-benzylpiperidines
✍ Scribed by M. A. Iorio; A. F. Casy
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 388 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Abstract
Examples are given of the conformationally dependent influence of 3‐substituents (methyl, n‐propyl, allyl, aryl, hydroxy and acyloxy) on the magnetic non‐equivalence of the benzylic methylene protons (N__CH__~2~Ph) of N‐benzylpiperidine as observable by ^1^H NMR. The results, together with data already reported, emphasise the value of ^1^H NMR studies of N‐benzyl derivatives in stereochemical investigations of substituted piperidines.