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A conditional knockout resource for the genome-wide study of mouse gene function

โœ Scribed by Skarnes, William C.; Rosen, Barry; West, Anthony P.; Koutsourakis, Manousos; Bushell, Wendy; Iyer, Vivek; Mujica, Alejandro O.; Thomas, Mark; Harrow, Jennifer; Cox, Tony


Book ID
111688996
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
366 KB
Volume
474
Category
Article
ISSN
0028-0836

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Conditional knockout mouse for tissue-sp
โœ Tomo-o Ishikawa; Harvey R. Herschman ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 592 KB

Cyclooxygenase-2 (Cox-2) modulates many normal functions, and appears to play a role in a wide variety of pathophysiologic conditions. Cox-2 gene expression is induced in many different cell types, in response to many distinct stimuli. We generated a conditional knockout mouse in which critical exon