A Concise Synthesis of (±)-Yaequinolone A2
✍ Scribed by Xinyun LI; Xing HUO; Junpeng LI; Xuegong SHE; Xinfu PAN
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 65 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0256-7660
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📜 SIMILAR VOLUMES
RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide
A 13-step synthesis of (±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable hetero-Claisen rearrangement. Small-molecule inhibitor