๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A Concise Synthesis of Silanediol-Based Transition-State Isostere Inhibitors of Proteases

โœ Scribed by Organ, Michael G.; Buon, Christophe; Decicco, Carl P.; Combs, Andrew P.


Book ID
120262324
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
37 KB
Volume
4
Category
Article
ISSN
1523-7060

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


A concise and enantioselective synthesis
โœ Bruce D. Dorsey; Kevin J. Plzak; Richard G. Ball ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 286 KB

Novel HIV-1 protease inhibitors have been prepared in a enantioselective manner via an Evans asymmetric aldol, Claisen rearrangement and icdolactonization. X-ray crystallographic analysis was used to confirm the absolute configuration of the newly created stereogenic centers. The alarming spread of

Solid-phase synthesis of potential aspar
โœ Jinglan Zhou; Andreas Termin; Melissa Wayland; Christine M. Tarby ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 189 KB

A series of 1,3-diamino-2-propanol derivatives have been synthesized on solid phase as potential aspar'tic acid protease irdaibitors. The developed methodology allows the incorporation of either an alkyl group or H at the R 2 site of hydroxyethylamine isostere.

Design and synthesis of substrate-based
โœ Yoshiaki Kiso ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 759 KB

## Peptidomimetic Human The human immunodeficiency virus (HIV) codas f o r an u.spartic protease known to be essential $)r retroviral mat urution and replicution. The H I V proteuw can rmignize Phe-Pro and Tyr-Pro sequences as the virus-specific cleuvuge site. These.fi.atures provided a basisJor th