A convenient synthesis of protected (R)-
β
J. Van Betsbrugge; D. TourwΓ©; B. Kaptein; H. Kierkels; R. Broxterman
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Article
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1997
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Elsevier Science
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French
β 397 KB
Boc-(R)-ot-phenylproline ethyl ester 1 was prepared in good yield starting from racemic phenylglycine. Condensation of phenylglycine ethyl ester with benzaldehyde furnished N-benzylidene phenylglycine ethyl ester which was allylated under phase transfer catalysis conditions. After acidic hydrolysis,