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A concise synthesis of l-4,4-difluoroglutamine

✍ Scribed by Patrick Meffre; Rajesh H Dave; Jacques Leroy; Bernard Badet


Book ID
104231911
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
55 KB
Volume
42
Category
Article
ISSN
0040-4039

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✍ Patrick Meffre; Rajesh H. Dave; Jacques Leroy; Bernard Badet πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 47 KB

Recently, we were led to re-examine our structural assignments of the final product reported in the above publication: further detailed analyses showed that the product obtained after amino group deprotection was actually L-4,4- difluoroglutamic acid 9 due to concomitant hydrolytic cleavage of the a

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A short synthesis of the nonproteinogenic amino acid, (2S,4R)-4-hydroxyornithine is described. Starting from racemic benzyl glycidol, the scaffold of the target compound was constructed in high enantio-and diastereoselectivity using Jacobsen's hydrolytic kinetic resolution (HKR) and regioselective o