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A concise route to phytosphingosine from lyxose
โ Scribed by Chun-Cheng Lin; Gang-Ting Fan; Jim-Min Fang
- Book ID
- 104253936
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 160 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Phytosphingosine was synthesized from the commercially available D-2,3-O -isopropylidene-D-lyxofuranose in 28% overall yield by a six-step procedure. This procedure is expedient and flexible for introduction of other lipid moieties on the phytosphingosine structure to make a variety of derivatives that can support the further exploration of their related biological functions.
๐ SIMILAR VOLUMES
Successful oxidation of a key thiazoline intermediate allows an efficient synthesis of tiazofurin in four steps from commercially available 1%-acetoxy-2%,3%,5%-tri-O-benzoyl-b-D-ribofuranose.