A concise regiospecific synthesis of 8,8-dimethyl-2H, 8H-pyrano[6, 5-h]quinolin-2-oneand related compounds
β Scribed by Zheng-Yu Yang; Yi Xia; Peng Xia; Arnold Brossi; Kuo-Hsiung Lee
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 111 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Synthesis of 6,7βdihydroβ10βtrideuteromethylβ6,8,8βtrimethylβ8Hβpyrano[3,2βg] chromoneβ2βcarboxylic acid (**10**) in high isotopic purity is described. The trideuteromethylation was achieved by sodium borodeuteride reduction of the ethoxycarbonyl derivative (**5**) of 7βhydroxyβ2,2,4βtr
A concise synthesis of 5-hydroxy-2,2-dimethyl-10-propyl-2H-pyrano[2,3-f ]chromen-8-one utilising a novel selective desulfonylation protocol is described. This method provides facile access to a key intermediate for the asymmetric synthesis of calanolide A.