𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 6,7-dihydro-10-trideuteromethyl-6, 8, 8-trimethyl-8H-pyrano[3,2-g]chromone-2-carboxylic acid

✍ Scribed by Norio Minami

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
236 KB
Volume
18
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Synthesis of 6,7‐dihydro‐10‐trideuteromethyl‐6,8,8‐trimethyl‐8H‐pyrano[3,2‐g] chromone‐2‐carboxylic acid (10) in high isotopic purity is described. The trideuteromethylation was achieved by sodium borodeuteride reduction of the ethoxycarbonyl derivative (5) of 7‐hydroxy‐2,2,4‐trimethylchroman‐8‐carboxylic acid (4). This labelled compound (10) is required for use as mass spectrometric stable isotope internal standard for the study of metabolic fate of 6,7‐dihydro‐6,8,8,10‐tetramethyl‐8H‐pyrano[3,2‐g] chromone‐2‐carboxylic acid (9), which is an orally active antiallergic agent.

📜 SIMILAR VOLUMES

Synthesis of 2-amino-7,8-dihydro-6(5H)-q
Synthesis of 2-amino-7,8-dihydro-6(5H)-quinazolinone, 2,4-diamino-7,8-dihydro-6(5H)-quinazolinone, 5,6,7,8-tetrahydro-2,6-quinazoline-diamine and 5,6,7,8-tetrahydro-2,4,6-quinazolinetriamine derivatives
✍ Petra Marinko; AleŠ Obreza; Lucija Peterlin-Mašič; AleŠ Krbavčič; Danijel Kikelj 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 379 KB

## Abstract __N__‐(2‐Amino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**9**) and __N__‐(2,4‐diamino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**6**) were synthesized from __N__‐(4‐oxocyclohexyl)acetamide (**5**) as novel peptidomimetic building blocks. With similar purpose, __N__‐(6‐oxo‐5,6,7,

ChemInform Abstract: Convenient Preparat
ChemInform Abstract: Convenient Preparation of 2,7,8-Trimethyl-6-hydroxychroman-2-carboxylic Acid (γ-Trolox).
✍ John A. Hyatt 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 23 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

3,4-Dihydro-3,4,6-trimethyl-2H,8H-pyrano
3,4-Dihydro-3,4,6-trimethyl-2H,8H-pyrano-[3,2g]-1,3-benzoxazin-2,8-dione, a Potential Fluorogenic Reporter Group Reagent for Esterases—Synthesis and Interaction with Chymotrypsin
✍ Trevor M. Kitson; Graham H. Freeman 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 111 KB

The synthesis of a novel "reporter group" reagent-3,4-dihydro-3,4,6-trimethyl-2H,8H-pyrano-[3,2g]-1,3-benzoxazin-2,8-dione (DTPBD)-is described. This compound has a cyclic carbamate functionality and thus, like the previously used 3,4-dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-one (DMNB), has the