A short and highly stereoselective synthesis of squalamine (1) was accomplished in 9 steps from easily available methyl chenodeoxycholanate (2). The advanced intermediate 7Ξ±,24R-dihydroxy-cholestan-3-one (9) was synthesized by using improved dehydrogenation of 4 followed by conjugate reduction and e
A Concise and Stereoselective Synthesis of Squalamine.
β Scribed by Dong-Hui Zhang; Feng Cai; Xiang-Dong Zhou; Wei-Shan Zhou
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 78 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A Concise, Stereoselective Synthesis of (Β±)-Geissoschizine. -The stereoselective synthesis of (Β±)-geissoschizine (VIII) is based on the addition of the enolate derived from 1-acetylindole (I) to the pyridinium salt (II) and cyclization of the resultant 1,4-dihydropyridine. -(BENNASAR, M.-L.;
## Abstract A simple and stereoselective method for the preparation of (__Z__)β2βsubstituted 1βaminocyclopropanecarboxylic acids is described. The common key step for these reaction sequences involves the stereoselective Tiβmediated coupling of benzyloxy nitrile and homoallylic alcohol. The resulti