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A computer model for hydrodynamic shearing of DNA (Gibb's phenomenon): Part II

✍ Scribed by S. Sitharama Iyengar; Stephen A. Quave

Publisher
Elsevier Science
Year
1979
Weight
157 KB
Volume
10
Category
Article
ISSN
0010-468X

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✦ Synopsis

This paper presents an extension of the distribution proposed during hydrodynamic shearing of DNA. In the Fourier least square approximation of uniform random distribution or a square wave, Gibb's phenomena occur at the boundariesβ€’ The same behavior occurs at the boundaries of the DNA strands undergoing hydrodynamic shearing of DNA. This hypothesis is corroborated by results from a computer simulation of hydrodynamic shearing of DNA. The evidence helps confirm the kinetic experiments of Britten and Kohne . Furthermore the results predict that sequence very near the end (0.2 LAMBDA) should be the most intact.

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A computer simulation model for the hydrodynamic shearing of DNA is presented. In this model the event space consists of a number of positions at which the DNA strand may break. The results of the model compared with the real world result are reported in this paper. Future endeavors to generalize th

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The distribution of breaks along the DNA strand in hydrodynamic shearing is unknown, and there is no real-world experiment which could directly determine this distribution. This paper presents an extension of the simulation model for hydrodynamic shearing of DNA reported in . An empirical model is