A computer model for hydrodynamic shearing of DNA — Further investigation on distribution of break lengths: Part III

✍ Scribed by S.Sitharama Iyengar

• Publisher: Elsevier Science
• Year: 1980
• Weight: 401 KB
• Volume: 12
• Category: Article
• ISSN: 0010-468X
• DOI: 10.1016/0010-468x(80)90064-1

✦ Synopsis

The distribution of breaks along the DNA strand in hydrodynamic shearing is unknown, and there is no real-world experiment which could directly determine this distribution.

This paper presents an extension of the simulation model for hydrodynamic shearing of DNA reported in . An empirical model is presented showing a good linear relationship between LAMBDA * and the number of fragments from each original strand. The average strand length is directly proportional to the number of fragments per strand. The traditional assumption of uniform random breaks along the DNA strand is supported by this model.

DNA modeling Hydrodynamic shearing Strand length