## Objective: We would like to improve the image reconstructions for both signal-to-noise ratio (snr) and spatial resolution characteristics for the small animal positron emission tomograph yap-pet, built at the department of physics of ferrara university. the three-dimensional (3d) filtered backpr
A computational study of the focus-of-attention EM-ML algorithm for PET reconstruction
β Scribed by Jens Gregor; Dean A. Huff
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 382 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0167-8191
No coin nor oath required. For personal study only.
β¦ Synopsis
The expectation-maximization maximum-likelihood (EM-ML) algorithm for image reconstruction in positron emission tomography (PET) essentially solves a large linear system of equations. In this paper, we study computational aspects of a recently developed preprocessing scheme for focusing the attention, and thus the computational resources, on a subset of the equations and unknowns in order to reduce the storage, computation, and communication requirements of the EM-ML algorithm. The approach is completely data-driven and uses no prior anatomic knowledge. The experimental results are obtained from runs on a small network of workstations using simulated phantom data as well as data obtained from a clinical ECAT 921 PET scanner.
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Both a mixture likelihood method and the EM algorithm are implemented to estimate the time-toonset-of and the time-to-death-from the tumor of interest in animal carcinogenicity studies. Both methods are implemented using Box's Complex Method for ΓΏnding the maximum likelihood estimates of parameters