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A computational study of conformers and rotamers of 3-substituted equatorial tetrahydro-2H-thiopyran-1-oxides (tetrahydrothiopyran-1-oxides, thiacyclohexane-1-oxides, thiane-1-oxides)

✍ Scribed by F. Freeman; F. Gomarooni; W.J. Hehre


Book ID
114141177
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
260 KB
Volume
535
Category
Article
ISSN
0166-1280

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πŸ“œ SIMILAR VOLUMES


A remarkable difference in the conformat
✍ L. Van Acker; M. Anteunis πŸ“‚ Article πŸ“… 1974 πŸ› Elsevier Science 🌐 French βš– 196 KB

The sulfoxide group shows a lot of interesting stereochemical features (2). In thiane-l-oxide the axial conformation (62% of the mixture at -9OOC) is favored by 175 Cal/mole (2). Introduction of a 3,3-dimethyl grouping reverses this axial