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A computational analysis of binding modes and conformation changes of MDM2 induced by p53 and inhibitor bindings

✍ Scribed by Jianzhong Chen,Jinan Wang,Weiliang Zhu…


Book ID
126358442
Publisher
Springer Netherlands
Year
2013
Tongue
English
Weight
899 KB
Volume
27
Category
Article
ISSN
0920-654X

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Conformational changes of the p53-bindin
✍ L. M. Espinoza-Fonseca; José G. Trujillo-Ferrara 📂 Article 📅 2006 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 310 KB

## Abstract Two 35‐ns molecular dynamics simulations of both ligated [mouse double minute protein 2 (MDM2^p53^)] and unligated (MDM2^apo^) structures of human MDM2 bound to the N‐terminal domain of the tumor suppressor p53 have been performed. Analysis of the dynamics revealed that the most flexibl