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Design, synthesis, and biological evaluation of imidazoline derivatives as p53–MDM2 binding inhibitors

✍ Scribed by Chunqi Hu; Xin Li; Weisi Wang; Lei Zhang; Lulu Tao; Xiaowu Dong; Rong Sheng; Bo Yang; Yongzhou Hu


Book ID
113495402
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
994 KB
Volume
19
Category
Article
ISSN
0968-0896

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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical