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A comprehensive catalogue of somatic mutations from a human cancer genome

✍ Scribed by Pleasance, Erin D.; Cheetham, R. Keira; Stephens, Philip J.; McBride, David J.; Humphray, Sean J.; Greenman, Chris D.; Varela, Ignacio; Lin, Meng-Lay; Ordóñez, Gonzalo R.; Bignell, Graham R.


Book ID
109898609
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
929 KB
Volume
463
Category
Article
ISSN
0028-0836

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Somatic mutations are hallmarks of cancer progression. We sequenced 26 matched human prostate tumor and constitutional DNA samples for somatic alterations in the SRD5A2, HPRT, and HSD3B2 genes, and identified 71 nucleotide substitutions. Of these substitutions, 79% (56/71) occur within a WKVnRRRnVWK