A comprehensive analysis of complex traits in problem 2A

✍ Scribed by S.H. Juo; T.H. Beaty; D.L. Duffy; N.E. Maestri; V.L. Prenger; J. Zeiger; H.H. Lei; J. Coresh

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 72 KB
• Volume: 14
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/(sici)1098-2272(1997)14:6<815::aid-gepi42>3.0.co;2-q

✦ Synopsis

We used descriptive analysis to investigate the relationship between affection status and five quantitative traits (Q1-Q5) in Problem 2A and results suggested the five quantitative traits fall into two groups. The first group comprised three strongly correlated traits, Q1-Q3, which underlie affection status, and the second group comprised Q4 and Q5, which are not directly related to affection status. Segregation and linkage analyses of traits Q1-Q3 and affection status from the first replicate detected one of the major loci for Q1 (MG1) linked to marker 14 on chromosome 5 (D5G14). Because our segregation analysis failed to show evidence of a major locus effect on Q2, and we overlooked the interaction between MG3 and sex, we did not detect either MG2 or MG3. Using Haseman-Elston sib-pair analysis [Haseman and Elston, 1972], we also examined the statistical power of Q1 and type I error rate (using the environmental factor as an index), for the remaining 199 replicates in the context of a genome screen.