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A Comparison of the hyphenated experiments GHMQC-TOCSY and GHSQC-TOCSY

✍ Scribed by Chad E. Hadden; Gary E. Martin; J.-K. Luo; Raymond N. Castle

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
462 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Heteronuclear shift correlations generally may be established using either the multiple quantum‐based GHMQC experiment or, alternately, the single quantum‐based GHSQC experiment. A scant few reports contained in the literature have compared results obtained with both types of sequences. The F~1~ resolution of the GHMQC and GHSQC experiments are compared using the polynuclear heteroaromatic naphtho‐[2′,1′:5,6]naphtho[2′,1′:4,5]thieno[2,3‐c]quinoline. Even when augmented by linear prediction in F~1~, the single quantum‐based GHSQC sequence gives better F~1~ resolution than its multiple quantum counterpart. To date, no studies have compared the hyphenated analogs of these experiments, GHMQC‐ and GHSQC‐ TOCSY. Similar conclusions to GHMQC/GHSQC are drawn for the comparison of GHMQC‐ and GHSQC‐ TOCSY experiments with inverted direct responses with, and without, linear prediction. The latter is recommended whenever there is congestion in both the F~2~ and F~1~ frequency domains.

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