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A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients

✍ Scribed by E.M. Rimmer; N.M. Milligan; A. Richens

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
464 KB
Volume
1
Category
Article
ISSN
0920-1211

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✦ Synopsis

The acute effect of oral administration of a single dose of vigabatrin, a new antiepileptic drug which acts by irreversible enzyme-activated inhibition of the brain enzyme, GABA-aminotransferase, on the photoconvulsive response in patients with photosensitive epilepsy, was compared with that of the established antiepileptic drug, sodium valproate. Both drugs significantly suppressed the photoconvulsive response in 3 out of 6 subjects. This result was interpreted as further evidence of vigabatrin's potential value in the future treatment of patients with epilepsy.

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