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A comparison of test methods for determining in vitro drug release from transdermal delivery dosage forms

โœ Scribed by David J. Mazzo; Eva K.F. Fong; Stephen E. Biffar


Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
346 KB
Volume
4
Category
Article
ISSN
0731-7085

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During formulation design of a once-daily controlled release matrix system of divalproex sodium, the in vitro dissolution test (USP II, 100 rpm, pH 6.8 buffer) was found to result in release rates that were slower than in vivo absorption. The test method also did not sufficiently discriminate formul