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A comparison of substrate dynamics in human CYP2E1 and CYP2A6

✍ Scribed by John P. Harrelson; Kirk R. Henne; Darwin O.V. Alonso; Sidney D. Nelson


Book ID
116294006
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
209 KB
Volume
352
Category
Article
ISSN
0006-291X

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Ontogeny of hepatic CYP1A2 and CYP2E1 ex
✍ Fawzy A. Elbarbry; Patrick J. McNamara; Jane Alcorn πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 404 KB πŸ‘ 1 views

## Abstract We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model to identify CYP‐mediated mechanisms underlying age‐dependent differences in susceptibility to toxicity. We evaluated CYP expressi