The influence of ageing on serum levels of tertiary tricyclic antidepressants (TCAs) was studied in 385 psychiatric inpatients treated daily with one of three TCAs: 157 patients with amitriptyline (154 f 47 mg, mean dose +SD), 183 with doxepin (177 f 59 mg) and 45 with clomipramine (153 f 51 mg). Th
A comparison of plasma and serum levels of two tricyclic antidepressants: Imipramine and desipramine
β Scribed by Joseph J. Saady; Valerie L. Bloom; N. Narasimhachari; Solomon C. Goldberg; Robert O. Friedel
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 162 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0033-3158
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π SIMILAR VOLUMES
A sensitive and specific method for the simultaneous determination of imipraminc and desipramine in the blood plasma of depressed patients under treatment that involves separation by gas chromatography and detection by mass fragmentography is described. Concentrations were determined by focusing the
Forty male volunteers were randomly assigned to one of four treatment groups on a double-blind basis: (1) Imipramine--25 mg t.d.s., (2) Viloxazine--50 mg t.d.s., (3) Placebo, and (4) Control--no tablets. Tests were carried out (1) before treatment, (2) 2 h after the first dose, (3) on Day 3 after 7