Gas chromatographic-mass fragmentographic determination of “steady-state” plasma levels of imipramine and desipramine in chronically treated patients

✍ Scribed by G. Belvedere; L. Burti; A. Frigerio; C. Pantarotto

• Publisher: Elsevier Science
• Year: 1975
• Tongue: English
• Weight: 614 KB
• Volume: 111
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)99280-x

✦ Synopsis

A sensitive and specific method for the simultaneous determination of imipraminc and desipramine in the blood plasma of depressed patients under treatment that involves separation by gas chromatography and detection by mass fragmentography is described. Concentrations were determined by focusing the mass spectrometer upon the ions at nl/e 280 and 235 for imipramine and 308. 236 and 114 for desipramine (N-acetyl derivative), while promazine was used as the internal standard (ions at 117/c' 284 and 238). Determinations are possible at levels as low as IO ng/ml in plasma.