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A comparative study on the physicochemical and biological stability of IgG1 and monoclonal antibodies during spray drying process

✍ Scribed by Ramezani, Vahid (author);Vatanara, Alireza (author);Najafabadi, Abdolhossein Rouholamini (author);Shokrgozar, Mohammad Ali (author);Khabiri, Alireza (author);Seyedabadi, Mohammad (author)


Book ID
125404275
Publisher
BioMed Central Ltd.
Year
2014
Tongue
English
Weight
410 KB
Volume
22
Category
Article
ISSN
1560-8115

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Removal of cysteinylation from an unpair
✍ Douglas D. Banks; Himanshu S. Gadgil; Gary D. Pipes; Pavel V. Bondarenko; Vipa H πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 348 KB

The antibody MAB007 was recently shown to be cysteinylated on an unpaired cysteine residue in the CDR3 variable region. Cysteinylation at this position was not complete and resulted in heterogeneous lots of MAB007 with respect to this posttranslational modification. In this report, a mild redox step