A comparative study of the reactions of thiophene-2-carboxanilides and related compounds
β Scribed by Ragab A. El-Sayed
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 292 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0009-3122
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π SIMILAR VOLUMES
The molecular mechanics calculations reported earlier for nitrogen heterocycles have now been extended to include the title compounds, and related molecules. It is in general possible to calculate these structures with an accuracy that compares favorably with experiment.
The syntheses of the thiophenic analogue of Moprolol (Id) and of its related compound l a are described. From a preliminary pharmacological evaluation compound Id seems worthy of further studies due to its notable P-blocking activity and its remarkable anti-platelet aggregation action. ## Synthese