A comparative study of the oxygen dissociation of mammalian hemoglobin

✍ Scribed by Foreman, Charles W.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1954
• Tongue: English
• Weight: 388 KB
• Volume: 44
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030440305

✦ Synopsis

The voluminous literature of the comparative aspects of oxygen-hemoglobin equilibrium has received several complete reviews (Redfield, '33 ; Florkin, '34 ; Prosser, '50).

Krogh and Leitch ('19) reported that, in both fresh and salt water, species of fish which frequently encounter low oxygen tensions have hemoglobins with higher oxygen affinities than those of species which seldom or never encounter low oxygen tensions. Redfield, Coolidge and Hurd ( '26) reported similar findings for several invertebrate species. These authors also pointed out that active species are likely to present hemoglobins with low oxygen affinities and high Bohr effects, while sluggish species are likely to possess hemoglobins with high oxygen affinities and low Bohr effects. Hall and AIcCntcheon ('38) revealed, f o r marine fish, data similar to those of Krogh and Leitch. Hall, Dill and Barron ('36) and Hall ( '37) stated that mammalian and avian species indigenous to the Chilean Andes revealed hemoglobins with higher oxygen affinities than those of their sea level counterparts. The works cited above indicate that the oxygen affinities of specific hemoglobins are correlated with habits and habitats and bear little relevancy to phylogenetic relationships.

This work was done in the laboratories of the Department of Physiology and a Thcse findings were presented as partial fulfillment of the requirements f o r