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A comparative study of manganese meso-sulfonatophenyl porphyrins: Contrast-enhancing agents for tumors

✍ Scribed by R.J. Fiel; D.A. Musser; E.H. Mark; R. Mazurchuk; J.J. Alletto

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 830 KB
Volume: 8
Category: Article
ISSN: 0730-725X
DOI: 10.1016/0730-725x(90)90097-l

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✦ Synopsis

Four manganese meso-sulfonatophenyl porphyrins were prepared, characterized and investigated for their potential as tumor-specific MRI contrast-enhancing agents in mice bearing subcutaneous implants of a mammary carcinoma (SMT-F). The trisulfonated tetraphenyl porphyrin, MnTPPS3 presented the most favorable profile: bio-distribution, tumor concentration and tumor relaxivity, when compared at 24 hr postinjection. Imaging experiments revealed that a time-dependent delineation of tumor morphology occurs in response to MnTPPS3 that appears to correlate with necrotic regions of the tumor.

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