The pharmacokinetics of mycophenolate mofetil (MMF) in liver transplant recipients may change because of pharmacokinetic interactions with coadministered immunosuppressants or because changes in the enterohepatic anatomy may affect biotransformation of MMF to mycophenolic acid (MPA) and enterohepati
β¦ LIBER β¦
A Comparative, Randomized Trial of Concentration-Controlled Sirolimus Combined With Reduced-Dose Tacrolimus or Standard-Dose Tacrolimus in Renal Allograft Recipients
β Scribed by Bechstein, W.O.; Paczek, L.; Wramner, L.; Squifflet, J.-P.; Zygmunt, A.J.
- Book ID
- 122351781
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 542 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0041-1345
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Posttransplant chronic renal failure, secondary to calcineurin inhibitor agents, is emerging as a major problem in liver transplantation. We report a randomized clinical trial comparing daclizumab, delayed low-dose tacrolimus (target trough level 4-8 ng/mL, starting day 4-6), Investigational Arm (n