A comparative immunohistochemical study of spontaneous and chemically induced pheochromocytomas in B6C3F1 mice
โ Scribed by Georgette D. Hill; Virgilio Pace; Elke Persohn; Christina Bresser; Joseph K. Haseman; Arthur S. Tischler; Abraham Nyska
- Book ID
- 111638477
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 825 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1046-3976
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## Abstract Groups of 52 B6C3F~1~ mice of each sex were maintained on a diet containing 1.25 or 0.6% phenacetin for 96 weeks and then fed a basal diet for 8 weeks. Control groups consisted of 50 mice of each sex and were fed a basal diet for 104 weeks. All animals were killed at the end of the expe
Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related incr