✦ LIBER ✦

A comparative analysis of quality of life data from a Southwest Oncology Group randomized trial of advanced colorectal cancer

✍ Scribed by Andrea B. Troxel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 105 KB
Volume: 17
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19980315/15)17:5/7<767::aid-sim820>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

Longitudinal quality of life measurements from an advanced-stage cancer clinical trial are analysed using a variety of methods, and the results compared. The methods used require di erent assumptions about the mechanism that produces the missing data. They include analyses that require the data to be missing completely at random; ÿxed-e ects models and weighted generalized estimating equations, which require missing at random data; and a fully parametric approach where the outcomes and the missingness mechanism are jointly modelled, allowing non-ignorable missing data. The data show evidence of non-random missingness, but a formal test of non-ignorable missing data is not signiÿcant.

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