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A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy

✍ Scribed by Els F. van der Molen; Guus E. Arends; Willianne L.D.M. Nelen; Nathalie J.M. van der Put; Sandra G. Heil; Tom K.A.B. Eskes; Henk J. Blom


Book ID
114486693
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
37 KB
Volume
182
Category
Article
ISSN
1097-6868

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5,10 Methylenetetrahydrofolate reductase
✍ Ou, C Y; Stevenson, R E; Brown, V K; Schwartz, C E; Allen, W P; Khoury, M J; Roz πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 19 KB πŸ‘ 2 views

Persons with a thermolabile form of the enzyme 5,lO methylenetetrahydrofolate reductase (MTHFR) have reduced enzyme activity and increased plasma homocysteine which can be lowered by supplemental folic acid. Thermolability of the enzyme has recently been shown to be caused by a common mutation (677C