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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

✍ Scribed by Graham, Robert R; Kozyrev, Sergey V; Baechler, Emily C; Reddy, M V Prasad Linga; Plenge, Robert M; Bauer, Jason W; Ortmann, Ward A; Koeuth, Thearith; Escribano, Ma Francisca González; Collaborative Groups, the Argentine and Spanish


Book ID
109919353
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
232 KB
Volume
38
Category
Article
ISSN
1061-4036

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Structural insertion/deletion variation
✍ Sergey V. Kozyrev; Susanna Lewén; Prasad M. V. Linga Reddy; Bernardo Pons-Estel; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 2 views

## Abstract ## Objective To determine whether specific isoforms of IRF5 are transcribed in patients with systemic lupus erythematosus (SLE) who have risk genotypes in the exon 1B donor splice site at single‐nucleotide polymorphism (SNP) no. rs2004640. ## Methods Peripheral blood mononuclear cell