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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

✍ Scribed by Dowdy, Steven F.; Lissy, Natalie A.; Davis, Penny K.; Irwin, Meredith; Kaelin, William G.

Book ID: 109771114
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 154 KB
Volume: 407
Category: Article
ISSN: 0028-0836
DOI: 10.1038/35036608

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## Abstract The E2F1 transcription factor can initiate proliferation or apoptosis, the latter by both transcription‐dependent and ‐independent mechanisms. Recently, an E2F1 mutant lacking the DNA binding domain, E2F1(180–437), has been implicated in degradation of MDMX and MDM2 proteins via lysosom