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A Collagen Peptide-Based Physical Hydrogel for Cell Encapsulation

✍ Scribed by Charles M. Rubert Pérez; Alyssa Panitch; Jean Chmielewski

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
446 KB
Volume
11
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Collagen peptide‐based hydrogels are prepared and characterized for application in 3D cell growth. Physical hydrogels are formed by covalently linking a collagen‐based peptide to an 8‐arm poly(ethylene glycol) star polymer. The resulting viscoelastic hydrogels have the ability to melt into a liquid‐like state near the melting temperature of the collagen triple helix and reform back into an elastic‐state at room temperature, adding a thermoresponsive feature to the material. In addition, the hydrogels possess desirable stiffness, as well as a highly cross‐linked network of pores where cells are found to reside, making the hydrogels promising scaffolds for the culture of hMSCs.magnified image

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