A Photocurable Hydrogel/Elastomer Composite Scaffold with Bi-Continuous Morphology for Cell Encapsulation
✍ Scribed by James W. S. Hayami; Stephen D. Waldman; Brian G. Amsden
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 735 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
A photocurable two‐phase scaffold with a bi‐continuous morphology was designed and characterized for the repair of load bearing soft tissues. An N‐methacrylate glycol chitosan (MGC) hydrogel phase was used to distribute the cells and enable cell growth once crosslinked. The second phase, an elastomerprepared from a star‐poly(ε‐caprolactone‐co‐D,L‐lactide) triacrylate, was used to enhance the mechanical properties. Chondrocytes were photocrosslinked within the bi‐continuous scaffolds and proliferated, increased metabolic activity and accumulated extracellular matrix over a 14 d culture period. Also during this time no significant material degradation was observed.magnified image