Tropical spastic paraparesis (TSP) and other chronic-progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I (HTLV-I). However, little is known about the cellular immune function in TSP. In the present st
A clinical neurophysiologic study of tropical spastic paraparesis
✍ Scribed by Dr. Albert C. Ludolph; Dr. Jacques Hugon; Dr. Gustavo C. Román; Dr. Peter S. Spencer; Dr. Bruce S. Schoenberg
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 682 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0148-639X
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✦ Synopsis
During a field study in the Seychelles Islands, 19 patients with tropical spastic paraparesis (TSP) were evaluated electrophysiologically. Methods of assessment included motor and sensory nerve conduction studies, electromyography, and analysis of the somatosensory evoked potentials after stimulation of the tibial and median nerves. The results showed that the most prominent feature of the disease, a spastic paraparesis, is accompanied by subclinical involvement of spinal sensory pathways and a comparatively minor peripheral sensorimotor polyneuropathy.
📜 SIMILAR VOLUMES
Human T-lymphotropic virus type I (HTLV-1)-associated tropical spastic paraparesis in Martinique has been identified in 54 patients, 49 women and 5 men. This myelopathy represents an endemic problem on this island and the earliest documented case dates from 1952. A blood transfusion history was obta